| Volume: 8; Issue: 1; June 2026 |
|---|
| Title : A BIRD'S EYE VIEW ON PRECISION IMMUNITY UTILIZING GENOME EDITING (CRISPR/Cas) TO ENGINEER INTRINSIC CROP RESISTANCE |
| Authour(s): Manal Khan and Aparna Pareek |
| Keywords: Base and prime editing, Biosafety, CRISPR/Cas genome editing, Plant disease resistance. |
| Abstract: Plant diseases are still affecting the world food security by lowering the production of large crops. In this review, the precision immunity concept, which involves the specific editing of endogenous plant genes to boost innate immunity, is critically assessed as the use of CRISPR/Cas-mediated genome editing to increase disease resistance. Authors reviewed the current literature on disruption of susceptibility (S) gene, control of immune signaling pathways, and allele-engineering in crops, including rice, wheat, and tomato. The review also covers the developments in multiplex editing, base editing, prime editing, and the unique functions of the system based on Cas12 (DNA targeting) and Cas13 (RNA targeting) in controlling DNA- and RNA-based pathogenesis. With respect to the editing outcomes, a few brief remarks are made on mechanistic aspects of repair pathways such as non-homologous end joining and homology-directed repair. Technical issues, regulatory changes, and biosafety issues are also evaluated. Altogether, as the existing evidence indicates, CRISPR-based approaches possess enormous capacity to aid in the creation of long- lasting and climate-resilient disease resistance in crops. |
| DOI: https://doi.org/10.46505/IJBI.2026.8109 |
| How to cite this article: Khan M. and Pareek A. (2026). A bird's eye view on precision immunity utilizing genome editing (CRISPR/Cas) to engineer intrinsic crop resistance. International Journal of Biological Innovations. 8(1): 83-93. https://doi.org/10.46505/IJBI.2026.8109 |
Pages: 89-93 | Viewed: 16 | Downloaded: 20| Download: PDF (2070KB) |
